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Publications

  • November 18, 2008

    CLINPAGE DISCUSSES STRATEGY BEHIND CLINSYS' ACQUISITION OF TRIALSTAT CLINICALANALYTICS
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  • July 7, 2008

    EMERGING CONTRACT RESEARCH ORGANIZATIONS: DRIVING SUCCESS

    Robert Ferguson and Ruchira Pathania
    korn/Ferry International

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    EMERGING CONTRACT RESEARCH ORGANIZATIONS: DRIVING SUCCESS

    The thought leadership of David E. Williams, Chief Executive Officer of Clinsys Clinical Research, Inc.®, is featured in Emerging Contract Research Organizations: Driving Success, a white paper by Bob Ferguson and Ruchira Pathania recently published by Korn/Ferry International. The paper explores how CROs are transforming the global pharmaceutical and biotechnology landscape and examines the strategies and leadership skills that are proving successful for these organizations.

    For additional information about Korn/Ferry International's thought leadership publications, please visit www.kornferry.com/ThoughtLeadership.

  • May 29, 2008

    SITE SPECIFIC ANDROGEN RECEPTOR SERINE PHOSPHORYLATION LINKED TO EPIDERMAL GROWTH FACTOR DEPENDENT GROWTH OF CASTRATION-RECURRENT PROSTRATE CANCER

    Liliana A. Ponguta, Christopher W. Gregory, Frank S. French and Elizabeth M. Wilson
    Journal of Biological Chemistry, doi:10.1074/jbc.M802392200

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    SITE SPECIFIC ANDROGEN RECEPTOR SERINE PHOSPHORYLATION LINKED TO EPIDERMAL GROWTH FACTOR DEPENDENT GROWTH OF CASTRATION-RECURRENT PROSTRATE CANCER

    Christopher W. Gregory, PhD, Senior Director of Clinical Development at Clinsys Clinical Research®, co-authored a scientific manuscript, Site specific androgen receptor serine phosphorylation linked to epidermal growth factor dependent growth of castration-recurrent prostate cancer, that was accepted by the Journal of Biological Chemistry on May 29, 2008. As an Adjunct Assistant Professor in the Department of Pathology and Laboratory Medicine at the University of North Carolina at Chapel Hill, Dr. Gregory has maintained a research relationship with his former colleagues since joining Clinsys. The published paper details the results of ongoing studies, which are an extension of the work performed by Dr. Gregory while he was at the university from 1994-2003.

    Abstract:

    Prostate cancer is a common disease in men that initiates in an environment of abundant circulating androgens. Proliferation of androgen-dependent prostate cancer cells is mediated by the androgen receptor, a ligand-dependent transcription factor that is activated by binding testosterone or dihydrotestosterone. Most prostate cancers regress in response to androgen deprivation therapy or anti-androgen treatment but eventually recur after a period of remission. An abundance of evidence suggests that the androgen receptor is critical to recurrent prostate cancer growth despite reduced circulating androgen levels, and the current study explored the influence of epidermal growth factor (EGF) on the function of the receptor. Knock-down of the androgen receptor using inhibitory RNAs decreased EGF stimulation of prostate cancer cell growth, demonstrating a mechanistic link between the receptor and the growth factor. EGF was shown to increase the phosphorylation of androgen receptor, thereby modulating the subcellular localization of the receptor. Mutation of a specific amino acid to prevent phosphorylation increased the interaction of the receptor with the regulatory subunits of DNA protein kinase, an enzyme involved in DNA repair in the nucleus of the cell. The results support a model in which androgen receptor activity increases castration-recurrent prostate cancer cell growth in response to EGF by site-specific phosphorylation that regulates nuclear-cytoplasmic shuttling through interactions with the DNA protein kinase regulatory complex.

  • April 28, 2008

    BACK TO BASICS: LAB TRAINING

    Nermina Nakas, MD, MPH
    ACRP 2008 Global Conference & Exhibition

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    BACK TO BASICS: LAB TRAINING

    As part of the ACRP 2008 Global Conference & Exhibition quality assurance track, Dr. Nermina Nakas, Director, Clinical Development, at Clinsys Clinical Research®, presented "Back to Basics: Lab Training." Dr. Nakas discussed the need in the clinical research arena for lab standardization across studies and the benefit of a single global reference range. She explained how Lab Normal/reference ranges are defined and identified challenges (Local vs. Central labs and US vs. SI lab units). Additionally, she discussed success strategies for optimum efficiency with lab data management.